Pattern recognition receptors in equine endotoxaemia and sepsis
Identifieur interne : 001E47 ( Main/Exploration ); précédent : 001E46; suivant : 001E48Pattern recognition receptors in equine endotoxaemia and sepsis
Auteurs : A. H. Werners ; C. E. Bryant [Royaume-Uni]Source :
- Equine Veterinary Journal [ 0425-1644 ] ; 2012-07.
English descriptors
- Teeft :
- Acad, Activates, Adaptive, Aderem, Agellin, Agonist, Aim2, Akira, Albicans, Antagonist, Bacterial infections, Bacterial lipoproteins, Biol, Bryant, Candida, Cell surface, Chem, Clin, Cytokine, Dendritic, Dendritic cells, Endoplasmic reticulum, Endotoxaemia, Endotoxin, Equine, Equine endotoxaemia, Equine medicine, Equine pattern recognition receptors, Equine pract, Foal, Golenbock, Host defense, Human monocytes, Immunol, Innate immunity, Ipaf, Kirschning, Latz, Ligand, Ligand binding, Lipid, Lipopolysaccharide, Macrophage, Mediates, Monocyte, Natl, Neonatal, Neonatal foals, Neutrophil, Nlrc4, Nlrp3, Nod1, Nod2, Pathogen, Peptidoglycan, Plo, Plos pathog, Proc, Prrs, Receptor, Recognises, Recurrent airway obstruction, Rheumatoid arthritis, Rhodobacter sphaeroides, Salmonella, Sepsis, Severe sepsis, Synthetic lipid, Takeuchi, Tlr2, Tlr4, Tlr4 antagonists, Tlr5, Tlr9, Tlrs, Tschopp, Werners.
Abstract
Pattern recognition receptors (PRRs) on host cells detect pathogens to activate innate immunity which, in turn, initiates inflammatory and adaptive immune responses. Successful activation of PRRs is, therefore, critical to controlling infections and driving pathogen‐specific adaptive immunity, but overactivity of PRRs causes systemic inflammation, which is detrimental to the host. Here we review the PRR literature as it relates to horses and speculate on the role PRRs may play in sepsis and endotoxaemia.
Url:
DOI: 10.1111/j.2042-3306.2012.00574.x
Affiliations:
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Successful activation of PRRs is, therefore, critical to controlling infections and driving pathogen‐specific adaptive immunity, but overactivity of PRRs causes systemic inflammation, which is detrimental to the host. Here we review the PRR literature as it relates to horses and speculate on the role PRRs may play in sepsis and endotoxaemia.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Werners, A H" sort="Werners, A H" uniqKey="Werners A" first="A. H." last="Werners">A. H. Werners</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bryant, C E" sort="Bryant, C E" uniqKey="Bryant C" first="C. E." last="Bryant">C. E. Bryant</name></region><name sortKey="Bryant, C E" sort="Bryant, C E" uniqKey="Bryant C" first="C. E." last="Bryant">C. E. Bryant</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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